Molecular effects of 1-naphthyl-methylcarbamate and solar radiation exposures on human melanocytes

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• 作者：Bianca Ferrucio^a ; ¹ ; ^{biferrucio@usp.br} ; Manoela Tiago^a ; ^{manoela.santos@usp.br} ; Richard D. Fannin^b ; ^{fannin@niehs.nih.gov} ; Liwen Liu^b ; ^{liuliw@niehs.nih.gov} ; Kevin Gerrish^b ; ^{gerrish@niehs.nih.gov} ; Silvya Stuchi Maria-Engler^a ; ^{silvya@usp.br} ; Richard S. Paules^b ; ² ; ^{paules@niehs.nih.gov} ; Silvia Berlanga de Moraes Barros^a ; ^{smbarros@usp.br}
• 关键词：Carbaryl ; 1-naphthyl-methylcarbamate ; Melanocytes ; Microarray ; Solar radiation ; Melanomagenesis
• 刊名：Toxicology in Vitro
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：38
• 期：Complete
• 页码：67-76
• 全文大小：825 K
• 卷排序：38

文摘

Carbaryl exposure may increase solar radiation deleterious effects on melanocytes. Carbaryl, but not solar radiation, induced an oxidative stress response. Carbaryl treatment upregulated the antioxidant gene HMOX1 and inhibited MITF. Combined treatment group induced synergistic DNA damage and cell cycle alteration. Data suggests carbaryl genotoxicity to melanocytes when associated with solar UV.