Sensitization to cat and dog allergen molecules in childhood and prediction of symptoms of cat and dog allergy in adolescence: A BAMSE/MeDALL study

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• 作者：Anna Asarnoj ; MD ; PhD^a ; ^b ; ^{anna.asarnoj@ki.se" class="auth_mail" title="E-mail the corresponding author} ; Carl Hamsten ; MSc ; PhD^a ; ^c ; ^&lowast ; ; Konrad Wadé ; n ; MSc^a ; ^&lowast ; ; Christian Lupinek ; MD ; PhD^g ; Niklas Andersson ; MSc^d ; Inger Kull ; RN ; PhD^d ; ^e ; ^f ; Mirela Curin ; PhD^g ; Josep Anto ; MD ; PhD^h ; ⁱ ; ^j ; ^k ; Jean Bousquet ; MD ; PhD^l ; Rudolf Valenta ; MD^g ; Magnus Wickman ; MD ; PhD^d ; ^e ; ^m ; ^&Dagger ; ; Marianne van Hage ; MD ; PhD^a ; ^&Dagger ;
• 关键词：Allergy ; allergen ; Barn/Children Allergy/Asthma Milieu Stockholm Epidemiologic ; birth cohort ; cat ; children ; dog ; IgE ; ISAC technology ; microarray ; pet ; sensitization ; Can f 1 ; Can f 5 ; Fel d 1 ; prediction
• 刊名：Journal of Allergy and Clinical Immunology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：137
• 期：3
• 页码：813-821.e7
• 全文大小：1947 K

文摘

Sensitization to individual cat and dog allergen molecules can contribute differently to development of allergy to these animals.

Objective

We sought to investigate the association between sensitization patterns to cat and dog allergen molecules during childhood and symptoms to these furry animals up to age 16 years.

Methods

Data from 779 randomly collected children from the Barn/Children Allergy/Asthma Milieu Stockholm Epidemiologic birth cohort at 4, 8, and 16 years were used. IgE levels to cat and dog were determined by using ImmunoCAP, and levels to allergen molecules were determined by using an allergen chip based on ISAC technology (Mechanisms for the Development of Allergy chip). Allergy was defined as reported rhinitis, conjunctivitis, or asthma at exposure to cat or dog.

Results

Cross-sectionally, IgE to Fel d 1 and cat extract had similar positive predictive values for cat allergy. IgE to Can f 1 showed a higher positive predictive value for dog allergy than dog extract IgE. Sensitizations to Fel d 1 and Can f 1 in childhood were significantly associated with symptoms to cat or dog at age 16 years. Polysensitization to 3 or more allergen molecules from cat or dog was a better longitudinal predictor of cat or dog symptoms than results of IgE tests with cat or dog allergen extract, respectively. Cross-sectionally, cat/dog-polysensitized children had higher IgE levels and more frequent symptoms to cat and dog than monosensitized children.

Conclusions

Sensitization to Fel d 1 and Can f 1 in childhood and polysensitization to either cat or dog allergen molecules predict cat and dog allergy cross-sectionally and longitudinally significantly better than IgE to cat or dog extract.