Alterations in the sputum proteome and transcriptome in smokers and early-stage COPD subjects
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- 作者：Bjoern Titz ; 1 ; bjorn.titz@pmi.com" class="auth_mail" title="E-mail the corresponding author ; Alain Sewer1 ; Thomas Schneider1 ; Ashraf Elamin1 ; Florian Martin1 ; Sophie Dijon ; Karsta Luettich ; Emmanuel Guedj ; Gregory Vuillaume ; Nikolai V. Ivanov ; Michael J. Peck ; Nveed I. Chaudhary ; Julia Hoeng ; Manuel C. Peitsch
- 关键词：COPD ; Smoking ; Sputum ; Systems toxicology ; Quantitative proteomics
- 刊名：Journal of Proteomics
- 出版年：2015
- 出版时间：14 October 2015
- 年：2015
- 卷：128
- 期：Complete
- 页码：306-320
- 全文大小：2479 K
文摘
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Clinical study with 240 subjects to assess effects of smoke exposure and COPD.
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Combined quantitative assessment of sputum proteome and transcriptome.
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Broad range of physiological smoke exposure effects captured.
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Effects largely attenuated upon long-term smoking cessation.
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Sputum demonstrates differences between COPD subjects and asymptomatic smokers.