Synthesis and reactions of 5,5-dinitrobarbituric acid

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• 作者：Langlet ; Abraham ; Latypov ; Nikolaj V. ; Wellmar ; Ulf ; Goede ; Patrick ; Bergman ; Jan
• 关键词：nitration ; nitro compounds ; nitrogen heterocycles
• 刊名：Tetrahedron Letters
• 出版年：2000
• 出版时间：March 18, 2000
• 年：2000
• 卷：41
• 期：12
• 页码：2011-2013
• 全文大小：71.6 K

文摘

Nitration of barbituric acid at 40°C gave the previously unknown 5,5-dinitrobarbituric acid (3), which readily underwent hydrolysis to dinitroacetylurea (5), which in turn could be hydrolysed in basic media to the potassium salt of dinitromethane. Alloxane was prepared in a one step procedure by thermal decomposition of 5,5-dinitrobarbituric acid in hot acetic acid.