Still Alive and Kicking: In-Vitro-Generated GM-CSF Dendritic Cells!

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• 作者：Manfred B. Lutz¹ ; ^{m.lutz@vim.uni-wuerzburg.de" class="auth_mail" title="E-mail the corresponding author} ; Kayo Inaba² ; Gerold Schuler³ ; Nikolaus Romani⁴
• 刊名：Immunity
• 出版年：2016
• 出版时间：19 January 2016
• 年：2016
• 卷：44
• 期：1
• 页码：1-2
• 全文大小：162 K

文摘

In a recent article (Helft et al., 2015), murine bone marrow (BM) cultures with granulocyte-macrophage colony-stimulating factor (GM-CSF) were analyzed for macrophage (“GM-Mac”) and dendritic cell (“GM-DC”) subsets, and the GM-DC subset was compared with conventional or classical DC (cDC) subsets isolated from peripheral and lymphoid organs of mice. The article was accompanied by a preview about the usefulness of murine BM-DC cultures in the study of DC biology (Guilliams and Malissen, 2015), insinuating that BM-DCs are not real DCs. But what is a real DC? To reanimate the “DC-ness” of murine BM-DCs, we collected some additional points that have not been addressed by recent papers or comments. We suggest their consideration for further discussion.