Epidermal Langerhans cells—Changing views on their function in vivo

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• 作者：Nikolaus Romani ; Susanne Ebner ; Christoph H. Tripp ; Vincent Flacher ; Franz Koch and Patrizia Stoitzner
• 关键词：Langerhans cells ; Dendritic cells ; In vivo ; Function ; Skin ; Epidermis ; Contact hypersensitivity ; Ablation ; CD207 ; Langerin
• 刊名：Immunology Letters
• 出版年：2006
• 出版时间：15 August 2006
• 年：2006
• 卷：106
• 期：2
• 页码：119-125
• 全文大小：242 K

文摘

New experimental models and methods have rendered the field of Langerhans cells very lively. An interesting and productive scientific debate as to the functions of Langerhans cells in vivo is currently going on. We have not yet reached the point where the “pros” would weigh out the “cons”, or vice versa. There is good evidence for a lack of Langerhans cell function and for down-regulatory Langerhans cell function in some models. On the other hand, there is also evidence for an active immunogenic and tolerogenic role of Langerhans cells. These recent developments will be discussed.