Effect of malondialdehyde on the ovalbumin structure and its interactions with T84 epithelial cells

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• 作者：Jasna Nikolić^a ; Andrijana Ne&scaron ; ić^a ; Milena Čavić^b ; Neda Đorđević^a ; Uro&scaron ; Anđelković^c ; ^d ; Marina Atanasković-Marković^e ; ^f ; Branko Drakulić^d ; Marija Gavrović-Jankulović^a ; ^{mgavrov@chem.bg.ac.rs}
• 关键词：DNPH ; 2 ; 4-dinitrophenylhydrazine ; DC ; dendritic cell ; DHP ; dihydropyridine ; IgE ; immunoglobulin E ; IgG ; immunoglobulin G ; MDA ; malondialdehyde ; MD ; molecular dynamics ; OVA ; ovalbumin ; TSLP ; thymic stromal lymphopoietin ; TNFα ; tumor necrosis factor α
• 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1861
• 期：2
• 页码：126-134
• 全文大小：1227 K
• 卷排序：1861

文摘

Malondialdehyde (MDA) covalently modifies Lys residues in OVA. MDA modified OVA reveals reduced IgE reactivity. OVA induced gene expression of pro-inflammatory cytokines in T84 epithelial cells. OVA and MDA modified OVA induced secretion of IL-33 in T84 epithelial cells.