A semi-synthetic natural product blocks collagen induced arthritis by preferentially suppressing the production of IL-6
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- 作者：Asha Kulkarni-Almeida ; 1 ; asha_almeida@yahoo.co.in" class="auth_mail" title="E-mail the corresponding author ; Meet Shah1 ; Mahesh Jadhav ; Bindu Hegde ; Jacqueline Trivedi ; Prabhu D. Mishra ; Girish B. Mahajan ; Shruta Dadarkar ; Ravindra Gupte ; Nilesh Dagia
- 关键词：Inflammation ; Rheumatoid arthritis ; IL-6 ; CIA
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：33
- 期：Complete
- 页码：63-69
- 全文大小：1029 K
文摘
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Compound A is a semi-synthetic compound derived from natural product.
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Compound A inhibits IL-6 secretion and not TNF-α.
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Compound A does not inhibit LPS-induced p38 MAPK activation.
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Compound A ameliorates the signs and symptoms of collagen-induced arthritis in mice.
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Compound A may be a good scaffold for drug discovery.