Vascular endothelial growth factor polymorphisms and risk of Alzheimer's disease: A meta-analysis

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• 作者：Dali He^a ; Weiping Lu^b ; Kai Chang^b ; Yueliang Liu^a ; Jun Zhang^a ; Zhaofang Zeng^a ; ^{zeng000@126.com}
• 关键词：AD ; Alzheimer's disease ; VEGF ; vascular endothelial growth factor ; VEGF gene ; vascular endothelial growth factor gene ; NINCDS&ndash ; ADRDA ; the National Institute of Neurological and Communicative Disorders and Stroke (NINCDS) and the Alzheimer's Disease a
• 刊名：Gene
• 出版年：2013
• 出版时间：15 April, 2013
• 年：2013
• 卷：518
• 期：2
• 页码：296-302
• 全文大小：1134 K

文摘

There were conflicting results about whether promoter polymorphisms (? 2578C/A, ? 1154G/A) of vascular endothelial growth factor (VEGF) gene is a risk factor of Alzheimer's disease (AD). To determine the relationship between them, a meta-analysis is needed urgently. We searched all the reports about VEGF promoter polymorphisms (? 2578C/A, ? 1154G/A) and AD risk from PubMed, Web of Science, Cochrane Collaboration and Google Scholar database for the period up to 1 August, 2012. A total of 7 studies were included in this meta-analysis. The pooled odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated applying fixed or random effects models. There was no significant association between VEGF ? 2578C/A polymorphisms and AD risk in all gene models (OR = 1.08, 95 % CI = 0.94-1.23 for A vs. C; OR = 1.19, 95 % CI = 0.89-1.59 for AA vs. CC; OR = 1.15, 95 % CI = 0.91-1.45 for AA vs. CC + CA; OR = 1.11, 95 % CI = 0.98-1.25 for AA + CA vs. CC). Similar results were provided in subgroup analysis by ethnicity. For the VEGF ? 1154G/A polymorphisms, lack of an association was also found (A vs. G: OR = 0.89, 95 % CI = 0.79-1.01; AA vs. GG: OR = 0.82, 95 % CI = 0.62-1.08; AA vs. GA + GG: OR = 0.89, 95 % CI = 0.68-1.16; AA + AG vs. GG: OR = 0.85, 95 % CI = 0.72-1.00). Conclusively, the result of this meta-analysis suggested that VEGF promoter polymorphisms (? 2578C/A, ? 1154G/A) might not contribute to the susceptibility of AD.