Protection against influenza A virus by vaccination with a recombinant fusion protein linking influenza M2e to human serum albumin (HSA)
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- 作者：Xupeng Mua ; Kebang Hub ; Mohan Shenc ; Ning Kongd ; Changhao Fud ; Weiqun Yand ; Anhui Weid ; weian_hui@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Influenza A virus ; M2e ; HSA ; Immune protection ; Vaccine
- 刊名：Journal of Virological Methods
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：228
- 期：Complete
- 页码：84-90
- 全文大小：1308 K
文摘
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A novel vaccine that link M2e of influenza A viruses with HSA was constructed.
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HSA/M2e could induce strong anti-M2e specific humoral immune responses.
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HSA/M2e was able to reduce viral load in the mice lungs and protect mice against challenge with influenza A virus.