Formulation and optimization of niosomes for topical diacerein delivery using 3-factor, 3-level Box-Behnken design for the management of psoriasis
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- 作者：Seyedeh Raziyeh Mahdavi Moghddama ; Abdul Ahadb ; abdulahad20@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; aahad@ksu.edu.sa" class="auth_mail" title="E-mail the corresponding author ; Mohd. Aqila ; aqilmalik@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Syed Sarim Imamc ; Yasmin Sultanaa
- 关键词：Diacerein ; Topical ; Niosomes ; Box-Behnken design ; Psoriasis
- 刊名：Materials Science & Engineering C
- 出版年：2016
- 出版时间：1 December 2016
- 年：2016
- 卷：69
- 期：Complete
- 页码：789-797
- 全文大小：1728 K
文摘
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Niosomes of diacerein were optimized by employing Box-Behnken design approach.
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Niosomes showed reasonable particle size, entrapment efficiency, and better skin penetration.
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CLSM showed that diacerein niosomes penetrated in the deeper layer of rat skin.
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In conclusion, topical delivery of diacerein was significantly enhanced by optimized niosomes.