Molecular iodine catalyzed synthesis of tetrazolo[1,5-a]-quinoline based imidazoles as a new class of antimicrobial and antituberculosis agents

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• 作者：Divyesh C. Mungra ; Harshad G. Kathrotiya ; ^{harshad_kathrotiya@yahoo.com} ; Niraj K. Ladani ; Manish P. Patel ; Ranjan G. Patel
• 关键词：Tetrazolo[1 ; 5-a]quinoline ; Imidazole ; MCR ; Iodine ; Antimicrobial activity ; Antituberculosis activity
• 刊名：Chinese Chemical Letters
• 出版年：2012
• 出版时间：December, 2012
• 年：2012
• 卷：23
• 期：12
• 页码：1367-1370
• 全文大小：294 K

文摘

A series of some new tetrazolo[1,5-a]quinoline based tetrasubstituted imidazole derivatives class=""boldFont"">6a-class=""boldFont"">l have been synthesized by a reaction of tetrazolo[1,5-a]quinoline-4-carbaldehyde class=""boldFont"">3a-class=""boldFont"">d, benzil class=""boldFont"">4, aromatic amine class=""boldFont"">5a-class=""boldFont"">c and ammonium acetate in the presence of iodine through one-pot multi-component reaction (MCR) approach. All the derivatives were screened for antimicrobial and antituberculosis activities and results worth further investigations.