Plasmodium falciparum mitochondrial genetic diversity exhibits isolation-by-distance patterns supporting a sub-Saharan African origin

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• 作者：Kazuyuki Tanabe ; Thibaut Jombart ; Shun Horibe ; Nirianne M.Q. Palacpac ; Hajime Honma ; Shin-Ichiro Tachibana ; Masatoshi Nakamura ; Toshihiro Horii ; Hirohisa Kishino ; Toshihiro Mita
• 关键词：mt ; mitochondria ; SNP ; single nucleotide polymorphism ; 胃S ; the standardized number of polymorphic sites per site ; 胃蟺 ; the average number of pair-wise nucleotide differences ; dS ; the mean number of synonymous substitutions per synonymous site ; dN ; the mean number of non-synonymous substitutions per non-synonymous site ; FST ; the Wright's fixation index of inter-population variance in allele frequencies ; MAF ; minor allele frequency ; serca ; sarcoplasmic/endoplasmic reticulum Ca2  ; +-transporti
• 刊名：Mitochondrion
• 出版年：November, 2013
• 年：2013
• 卷：13
• 期：6
• 页码：630-636
• 全文大小：613 K

文摘

The geographical distribution of single nucleotide polymorphism (SNP) in the mitochondrial genome of the human malaria parasite m>Plasmodium falciparumm> was investigated. We identified 88 SNPs in 516 isolates from seven parasite populations in Africa, Southeast Asia and Oceania. Analysis of the SNPs postulated a sub-Saharan African origin and recovered a strong negative correlation between within-population SNP diversity and geographic distance from the putative African origin over Southeast Asia and Oceania. These results are consistent with those previously obtained for nuclear genome-encoded housekeeping genes, indicating that the pattern of inheritance does not substantially affect the geographical distribution of SNPs.