Early CSF and Serum S100B Concentrations for Outcome Prediction in Traumatic Brain Injury and Subarachnoid Hemorrhage
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- 作者：Isabel Kellermann isabel.kellermann@web.de" class="auth_mail" title="E-mail the corresponding author ; Andrea Kleindienst andrea.kleindienst@uk-erlangen.de" class="auth_mail" title="E-mail the corresponding author ; Nirjhar Hore nirjhar.hore@uk-erlangen.de" class="auth_mail" title="E-mail the corresponding author ; Michael Buchfelder michael.buchfelder@uk-erlangen.de" class="auth_mail" title="E-mail the corresponding author ; Sebastian Brandner ; sebastian.brandner@uk-erlangen.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Biomarker ; S100B ; Neurotrauma ; Neuroproteins ; Cerebrospinal fluid
- 刊名：Clinical Neurology and Neurosurgery
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：145
- 期：Complete
- 页码：79-83
- 全文大小：406 K
文摘
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Prognostic value of S100B in TBI, SAH and meningitis at 6 months following treatment.
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Significant correlation between serum S100B and GOS in overall cohort, TBI and SAH (p < 0.05).
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Significant correlation between CSF S100B and GOS in SAH (p < 0.05).
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Serum S100B >0.7 μg/l correlated with 100% mortality.
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CSF S100B sensitive to small influences with EVD exchange causing significant increase (p < 0.005).