CIZ1, a p21^Cip1/Waf1-interacting protein, functions as a tumor suppressor in vivo

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• 作者：Rio Nishibe ; Wataru Watanabe ; Takeshi Ueda ; Norimasa Yamasaki ; Richard Koller ; Linda Wolff ; Zen-ichiro Honda ; Motoaki Ohtsubo ; Hiroaki Honda
• 关键词：CIZ1 (Cip1 interacting zinc finger protein 1) ; p21Cip1/Waf1 ; Cell proliferation ; Tumorigenesis
• 刊名：FEBS Letters
• 出版年：2013
• 出版时间：21 May, 2013
• 年：2013
• 卷：587
• 期：10
• 页码：1529-1535
• 全文大小：1104 K

文摘

CIZ1 is a nuclear protein involved in DNA replication and is also implicated in human diseases including cancers. To gain an insight into its function in vivo, we generated mice lacking Ciz1. Ciz1-deficient (Ciz1^?/?) mice grew without any obvious abnormalities, and Ciz1^?/? mouse embryonic fibroblasts (MEFs) did not show any defects in cell cycle status, cell growth, and DNA damage response. However, Ciz1^?/? MEFs were sensitive to hydroxyurea-mediated replication stress and susceptible to oncogene-induced cellular transformation. In addition, Ciz1^?/? mice developed various types of leukemias by retroviral insertional mutagenesis. These results indicate that CIZ1 functions as a tumor suppressor in vivo.