Sarcopenia as a Risk Factor for Cognitive Deterioration in Community-Dwelling Older Adults: A 1-Year Prospective Study

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• 作者：Shu Nishiguchi ; RPT ; MSc^a ; ^b ; ^{shu.nsgc.kupt@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Minoru Yamada ; RPT ; PhD^c ; Hidehiko Shirooka ; RPT^a ; Yuma Nozaki ; RPT^a ; Naoto Fukutani ; RPT ; MSc^a ; Yuto Tashiro ; RPT ; MSc^a ; Hinako Hirata ; RPT^a ; Moe Yamaguchi ; RPT^a ; Seishiro Tasaka ; RPT^a ; Tomofumi Matsushita ; RPT^a ; Keisuke Matsubara ; BS^a ; Tadao Tsuboyama ; MD ; PhD^a ; Tomoki Aoyama ; MD ; PhD^a
• 关键词：Sarcopenia ; cognitive deterioration ; community-dwelling older adults ; prospective study
• 刊名：Journal of the American Medical Directors Association
• 出版年：2016
• 出版时间：1 April 2016
• 年：2016
• 卷：17
• 期：4
• 页码：372.e5-372.e8
• 全文大小：259 K

文摘

The purpose of this 1-year prospective study was to determine whether sarcopenia is an independent risk factor of cognitive deterioration in community-dwelling older adults.

Study Design

One-year prospective study.

Setting

Japanese community.

Participants

A total of 131 community-dwelling older adults aged 65 years and older participated in this study.

Measurements

We defined sarcopenia using the diagnostic algorithm recommended by the Asian Working Group for Sarcopenia, and the participants were classified into the sarcopenia and normal groups according to this definition. The participants' cognitive functions were assessed using the Mini-Mental State Examination (MMSE) during pre- and postdata collection (after 1 year).

Results

The rate of change in pre- and post-MMSE scores during the follow-up term was significantly different between the 2 groups (normal group, −0.32 ± 8.39%; sarcopenia group, −5.86 ± 5.16%; P = .002). The analysis of covariance, adjusted for demographic data and the pre-MMSE scores, showed a significant change in the MMSE scores between the normal and sarcopenia group (F = 9.30, P = .003). Furthermore, in the multivariate logistic regression analysis, the cognitive function was significantly more likely to deteriorate (defined as a loss of at least 2 points of MMSE) in the sarcopenia group during the follow-up term (odds ratio: 7.86, 95% confidence interval: 1.53–40.5).

Conclusions

Sarcopenia was identified as an independent risk factor of cognitive deterioration in community-dwelling older adults during the 1-year study period.