Impaired long-trace eyeblink conditioning in a Tg2576 mouse model of Alzheimer's disease

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• 作者：Yasushi Kishimoto ; ^{kishimot@kph.bunri-u.ac.jp} ; Ikuko Oku ; Atsuko Nishigawa ; Akiko Nishimoto ; Yutaka Kirino
• 关键词：Aging ; Alzheimer's disease ; Eyeblink conditioning ; Hippocampus ; Trace conditioning
• 刊名：Neuroscience Letters
• 出版年：2012
• 出版时间：6 January 2012
• 年：2012
• 卷：506
• 期：1
• 页码：155-159
• 全文大小：567 K

文摘

Eyeblink conditioning has been used for assessing cognitive performance in cases of human neurodegenerative diseases including Alzheimer's disease (AD). Here, we tested and compared the delay and long-trace interval (TI = 500 ms) eyeblink conditionings in a Tg2576 mouse model of AD, at the age of 3, 6, and 12 months. Tg2576 mice exhibited significant impairment in trace conditioning at 6 months of age. In contrast, delay conditioning was not impaired in Tg2576 mice even at 12 months. These findings indicate that the long-TI eyeblink conditioning is more susceptible to age-related cognitive deterioration than delay conditioning in Tg2576 mice. The long-trace eyeblink conditioning could be a potential tool for detecting early cognitive deficits in AD mouse model.