PCDH10 is required for the tumorigenicity of glioblastoma cells

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• 作者：Kanae Echizen ; Mitsutoshi Nakada ; Tomoatsu Hayashi ; Hemragul Sabit ; Takuya Furuta ; Miyuki Nakai ; Ryo Koyama-Nasu ; Yukiko Nishimura ; Kenzui Taniue ; Yasuyuki Morishita ; Shinji Hirano ; Kenta Terai ; Tomoki Todo ; Yasushi Ino ; Akitake Mukasa ; Shunsaku Takayanagi ; Ryohei Ohtani ; Nobuhito Saito ; Tetsu Akiyama
• 关键词：Protocadherin PCDH10 ; OL-protocadherin ; Glioblastoma ; Tumorigenicity ; Proliferation
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：31 January, 2014
• 年：2014
• 卷：444
• 期：1
• 页码：13-18
• 全文大小：1663 K

文摘

Protocadherin10 (PCDH10)/OL-protocadherin is a cadherin-related transmembrane protein that has multiple roles in the brain, including facilitating specific cell-cell connections, cell migration and axon guidance. It has recently been reported that PCDH10 functions as a tumor suppressor and that its overexpression inhibits proliferation or invasion of multiple tumor cells. However, the function of PCDH10 in glioblastoma cells has not been elucidated. In contrast to previous reports on other tumors, we show here that suppression of the expression of PCDH10 by RNA interference (RNAi) induces the growth arrest and apoptosis of glioblastoma cells in vitro. Furthermore, we demonstrate that knockdown of PCDH10 inhibits the growth of glioblastoma cells xenografted into immunocompromised mice. These results suggest that PCDH10 is required for the proliferation and tumorigenicity of glioblastoma cells. We speculate that PCDH10 may be a promising target for the therapy of glioblastoma.