Chemosurgery with trichloroacetic acid for allergic rhinitis: Evaluation of the efficacy in terms of inhibition of Th2 cell infiltration

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• 作者：Kazuo Yao ; Kentaro Sato ; Daisuke Usui ; Rika Kurihara ; Makito Okamoto ; Yoshiaki Iguchi ; Koichiro Nishiyama
• 关键词：CKR4 ; CD4 ; Mirror-image section ; Immunohistochemical staining
• 刊名：Auris Nasus Larynx
• 出版年：2009
• 出版时间：June 2009
• 年：2009
• 卷：36
• 期：3
• 页码：292-299
• 全文大小：662 K

文摘

Objective

To examine local inhibition of Th2 cell infiltration as the basis for demonstrating the superior clinical effect of trichloroacetic acid (TCA) treatment for allergic rhinitis.

Methods

Mirror-image sections of the inferior turbinate mucosae of both sides were obtained from 26 patients who underwent TCA treatment on one side because of the nasal anatomy status and who eventually underwent bilateral inferior turbinectomy because of failure of the TCA treatment. Th2 cell counts, defined as counts of cells positive for anti-CD4 antibody and anti-CKR4 antibody (double-positive cells) were obtained for comparison. The differences between the TCA-treated and non-TCA-treated mucosae were analyzed by Mann–Whitney's U test.

Results

Th2 cell infiltration was characteristically found just beneath the epithelium and in the periglandular areas. The mean count ± standard deviation of Th2 cells was 4.96 ± 2.72 cells/mm² in the TCA-treated mucosae and 12.03 ± 7.19 cells/mm² in the non-treated mucosae, the difference being significant (p < 0.01).

Conclusion

TCA treatment induces inhibition of Th2 cell infiltration. This corroborates the suggestion that TCA treatment can inhibit local type I allergic reactions.