Extracellular Vesicles from Trypanosoma brucei Mediate Virulence Factor Transfer and Cause Host Anemia
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- 作者：Anthony J. Szempruch1 ; 5 ; Steven E. Sykes1 ; 5 ; Rudo Kieft1 ; Lauren Dennison1 ; Allison C. Becker1 ; Anzio Gartrell1 ; William J. Martin2 ; Ernesto S. Nakayasu3 ; Igor C. Almeida4 ; Stephen L. Hajduk1 ; 6 ; shajduk@bmb.uga.edu" class="auth_mail" title="E-mail the corresponding author ; John M. Harrington1 ; 6 ; johnmharrin@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：14 January 2016
- 年：2016
- 卷：164
- 期：1-2
- 页码：246-257
- 全文大小：3046 K
文摘
Trypanosoma brucei produce extracellular vesicles (EVs) from membrane nanotubes
EVs transfer the serum resistance-associated protein (SRA) to trypanosomes
EV transfer of SRA coveys resistance to human innate immunity
EVs fusion with RBCs transfers lipids and proteins and causes anemia