Making Sense of the Yeast Sphingolipid Pathway

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• 作者：Má ; rton Megyeri¹ ; ² ; Howard Riezman³ ; Maya Schuldiner¹ ; ^{maya.schuldiner@weizmann.ac.il} ; Anthony H. Futerman²
• 关键词：SL ; sphingolipids ; Cer ; ceramide ; CerS ; Cer synthase ; SPT ; serine palmitoyl transferase ; ER ; endoplasmic reticulum ; 3-KDS ; 3-ketodihydrosphingosine ; LCB ; long chain base ; DHS ; dihydrosphingosine (sphinganine) ; DHCer ; dihydroCer ; PHS ; phytosphingosine (4-OH sphinganine) ; PHCer ; phytoCer ; IPC ; inositol phosphoryl Cer ; MIPC ; mannosyl IPC ; M(IP)2C ; mannosyl di-IPC ; AbA ; Aureobasidin A ; Rf ; retention factor ; TLC ; thin layer chromatography ; NBD ; 7-Nitrobenz-2-oxa-1 ; 3-diazol-4-yl
• 刊名：Journal of Molecular Biology
• 出版年：2016
• 出版时间：4 December 2016
• 年：2016
• 卷：428
• 期：24
• 页码：4765-4775
• 全文大小：621 K
• 卷排序：428

文摘

The yeast (S. cerevisiae) SL metabolic pathway is introduced and the levels and roles of dihydro and phyto forms are highlighted. Yeast SL nomenclature is clarified and compared to other standard nomenclatures. Levels of various SL species in the branches of the metabolic pathways are discussed. Distinct roles for hydroxylation, acyl chain length, and unsaturation are discussed based on the biophysical properties of the lipids.