Reversible photoswitching aggregation and dissolution of spiropyran-functionalized copolymer and light-responsive FRET process

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• 作者：Lei-Xiao Yu ; Yang Liu ; Si-Chong Chen ; ^{chensichong@scu.edu.cn" class="auth_mail} ; Yue Guan ; Yu-Zhong Wang ; ^{yzwang@scu.edu.cn" class="auth_mail}
• 关键词：RAFT polymerization ; Spiropyran ; Light-responsive ; Self-assemble ; Fluorescence resonance energy transfer (FRET)
• 刊名：Chinese Chemical Letters
• 出版年：March, 2014
• 年：2014
• 卷：25
• 期：3
• 页码：389-396
• 全文大小：2147 K

文摘

Well-defined, reversibly light-responsive amphiphilic diblock copolymer grafted with spiropyran, was prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization. The copolymer self-assembles into polymeric micelles in water and exhibits reversible dissolution and re-aggregation characteristics upon ultraviolet (UV) and visible (Vis)-light irradiation. The fluorescence response of spiropyran immobilized onto the copolymer was light switchable. When nitrobenzoxadiazolyl derivative (NBD) dyes are encapsulated into the core of the micelles, a reversible, light-responsive, dual-color fluorescence resonance energy transfer (FRET) system is constructed and processed, which is well regulated by alternatively UV/vis irradiation. We anticipate these photoswitchable and FRET lighting up nanoparticles will be useful in drug delivery and cell imaging or tracking synchronously.