Synthesis and structure–activity relationships of nitrobenzyl phosphoramide mustards as nitroreductase-activated prodrugs

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• 作者：Longqin Hu^a ; ^b ; ^{longhu@rutgers.edu"" rel=""nofollow} ; ^{longhu@rci.rutgers.edu"" rel=""nofollow} ; Xinghua Wu^a ; Jiye Han^a ; Lin Chen^a ; Simon O. Vass^c ; Patrick Browne^d ; Belinda S. Hall^e ; Christopher Bot^e ; Vithurshaa Gobalakrishnapillai^e ; Peter F. Searle^c ; Richard J. Knox^d ; Shane R. Wilkinson^e
• 关键词：Nitroreductase ; Prodrug ; Phosphoramide mustard ; Antiproliferative ; Trypanosoma ; Leishmania
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2011
• 出版时间：1 July 2011
• 年：2011
• 卷：21
• 期：13
• 页码：3986-3991
• 全文大小：471 K

文摘

A series of nitrobenzyl phosphoramide mustards and their analogs was designed and synthesized to explore their structure–activity relationships as substrates of nitroreductases from Escherichia coli and trypanosomes and as potential antiproliferative and antiparasitic agents. The position of the nitro group on the phenyl ring was important with the 4-nitrobenzyl phosphoramide mustard (1) offering the best combination of enzyme activity and antiproliferative effect against both mammalian and trypanosomatid cells. A preference was observed for halogen substitutions ortho to benzyl phosphoramide mustard but distinct differences were found in their SAR of substituted 4-nitrobenzyl phosphoramide mustards in E. coli nitroreductase-expressing cells and in trypanosomatids expressing endogenous nitroreductases.