Mustard vesicants alter expression of the endocannabinoid system in mouse skin
详细信息 查看全文
- 作者：Irene M. Wohlmana ; Gabriella M. Compostoa ; Diane E. Heckb ; Ned D. Heindelc ; C. Jeffrey Laceyc ; Christophe D. Guillonc ; Robert P. Casillasd ; Claire R. Croutchd ; Donald R. Gereckea ; Debra L. Laskina ; Laurie B. Josepha ; Jeffrey D. Laskine ; jlaskin@eohsi.rutgers.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：AEA ; anandamide ; AG ; 2-arachidonoyl glycerol ; CB1 ; cannabinoid receptor 1 ; CB2 ; cannabinoid receptor 2 ; CB receptor ; cannabinoid receptor ; FAAH ; fatty acid amide hydrolase ; NM ; nitrogen mustard ; OEA ; oleyolethanolamide ; PEA ; palmitoylethanolamide ; PPARα ; peroxisome proliferator activated receptor alpha ; SM ; sulfur mustard
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：15 July 2016
- 年：2016
- 卷：303
- 期：Complete
- 页码：30-44
- 全文大小：4257 K
文摘
- •
Sulfur mustard and nitrogen mustard are potent skin vesicants.
- •
The endocannabinoid system regulates keratinocyte growth and differentiation.
- •
Vesicants are potent inducers of the endocannabinoid system in mouse skin.
- •
Endocannabinoid proteins upregulated are FAAH, CB1, CB2 and PPARα.
- •
FAAH inhibitors suppress vesicant-induced inflammation in mouse skin.