Chemical and toxicological characteristics of conventional and low-TSNA moist snuff tobacco products
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- 作者：Min-Ae Songa ; b ; Catalin Marianb ; c ; Theodore M. Braskyb ; Sarah Reisingerb ; Mirjana Djordjevicd ; Peter G. Shieldsb ; peter.shields@osumc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：CPDB ; California&rsquo ; s ; CPF ; carcinogenic potency factor ; DMSO ; dimethyl sulfoxide ; EPA ; Environmental Protection Agency ; FDA ; Food and Drug Administration ; HNSCC ; head and neck squamous cell carcinoma ; HPHCs ; harmful and potentially harmful constituents ; IARC ; International Agency for Research on Cancer ; LOD ; limit of detection ; LOQ ; limit of quantification ; MN ; micronucleus ; NAB ; N&prime ; -Nitrosoanabasine ; NAT ; N&prime ; -Nitrosoanatabine ; NDMA ; N&prime ; -nitrosodimethylamine ; NNK ; nicotine-der
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：14 March 2016
- 年：2016
- 卷：245
- 期：Complete
- 页码：68-77
- 全文大小：1354 K
文摘
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The first study to apply multidimensional data analysis to determine the similarity and differences in features of chemicals and cancer risks among the most popular moist snuff products worldwide.
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Identification of clearly different toxicant constituents through multidimensional data approach for a wide range of chemicals.
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Differences in toxicant levels when expressed on a dry weight basis, but less variation when results are normalized for nicotine content.
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Higher cancer risk estimates for dry weight determinations than nicotine normalized determination.