In vitro metabolism of N′-Nitrosonornicotine catalyzed by cytochrome P450 2A13 and its inhibition by nicotine, N′-Nitrosoanatabine and N′-Nitrosoanabasine
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- 作者：Xingyu Liua ; Jie Zhanga ; Limeng Wangb ; Bicheng Yangc ; Chen Zhanga ; Wei Liua ; correspondingbj@sina.com" class="auth_mail" title="E-mail the corresponding author ; Jun Zhoua ;
- 关键词：NNN ; Cytochrome P450 ; Metabolism ; Inhibition
- 刊名：Chemico-Biological Interactions
- 出版年：2016
- 出版时间：25 December 2016
- 年：2016
- 卷：260
- 期：Complete
- 页码：263-269
- 全文大小：378 K
文摘
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The interactions of NNN with NAT and NAB were firstly investigated.
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NNN metabolism was competitively inhibited by nicotine, NAT and NAB.
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Nicotine, NAT and NAB produced similar inhibitory potency on NNN metabolism.