Determination of tobacco-specific nitrosamines in replacement liquids of electronic cigarettes by liquid chromatography-tandem mass spectrometry

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• 作者：Hyun-Ji Kim^a ; Ho-Sang Shin^b ; ^{hshin@kongju.ac.kr}
• 关键词：Liquid chromatography&ndash ; tandem mass spectrometry ; Tobacco-specific nitrosamines ; Electronic cigarette ; Replacement liquids
• 刊名：Journal of Chromatography A
• 出版年：2013
• 出版时间：24 May, 2013
• 年：2013
• 卷：1291
• 期：Complete
• 页码：48-55
• 全文大小：1032 K

文摘

A liquid chromatography-tandem mass spectrometric method was described to detect tobacco-specific nitrosamines (TSNAs) in replacement liquids of electronic cigarettes. Solid-phase extraction (SPE) and liquid-liquid extraction (LLE) were compared to each other to select the optimum clean-up method. Under the established condition, the limits of quantification of N¡ä-nitrosonornicotine (NNN), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), N¡ä-nitrosoanabasine (NAB), and N¡ä-nitrosoanatabine (NAT) were 0.06, 0.07, 0.06, and 0.04 ¦Ìg/L respectively, by using 0.5 mL of replacement liquids, respectively, and the relative standard deviation was less than 10 % at concentrations of 5.0 and 25.0 ¦Ìg/L. The concentrations of TSNAs were measured in concentration ranges of 0.34-60.08 ¦Ìg/L (64.8 % detection frequency) for NNN, 0.22-9.84 ¦Ìg/L (88.6 % detection frequency) for NNK, 0.11-11.11 ¦Ìg/L (54.3 % detection frequency) for NNB, and 0.09-62.19 ¦Ìg/L (75.2 % detection frequency) for NAT in 105 replacement liquid brands from 11 electronic cigarette companies purchased in the Korean market.