Targeting the nNOS/peroxynitrite/calpain system to confer neuroprotection and aid functional recovery in a mouse model of TBI
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- 作者：Mushfiquddin Khana ; 1 ; khanm@musc.edu" class="auth_mail" title="E-mail the corresponding author ; Tajinder S Dhammua ; 1 ; dhammu@musc.edu" class="auth_mail" title="E-mail the corresponding author ; Fumiyo Matsudaa ; b ; fumiyo@health.nop.kagoshima-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Balasubramaniam Annamalaia ; annamal@musc.edu" class="auth_mail" title="E-mail the corresponding author ; Tejbir Singh Dhindsaa ; dhindsat@musc.edu" class="auth_mail" title="E-mail the corresponding author ; Inderjit Singha ; singhi@musc.edu" class="auth_mail" title="E-mail the corresponding author ; Avtar K. Singhc ; d ; singha@musc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：BH4 ; tetrahydrobiopterin ; CCI ; controlled cortical impact ; FeTPPS ; 5 ; 10 ; 15 ; 20-tetrakis(4-sulfonatophenyl) porphyrinato iron (III) ; HgCl2 ; mercuric chloride ; GSNO ; S-nitrosoglutathione ; MBP ; myelin basic protein ; NeuN ; neuronal nuclear protein ; 7-NI ; 7-nitroindazole ; nNOS ; neuronal nitric oxide synthase ; NO ; nitric oxide ; 3-NT ; 3-nitrotyrosine ; ONOO&minus ; peroxynitrite ; Sham ; sham-operated animals ; SIN-1 ; 3-morpholinosyndonimine ; TBI ; traumatic brain injury.
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：1630
- 期：Complete
- 页码：159-170
- 全文大小：4694 K
文摘
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TBI increases the activities of nNOS/calpain system and the levels of peroxynitrite.
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GSNO inhibits the activities of nNOS/calpain and reduces the levels of peroxynitrite.
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GSNO reduces TBI-induced neurodegeneration and aids in functional recovery.
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Mechanism of 3-nitrotyrosination of calpain is associated with its aberrant activity.
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Mechanism of S-nitrosylation of nNOS/calpain is associated with neuroprotection.