Synthesis of 3-substituted carboxylate/carboxamide flavone derivatives from 4-hydroxycoumarin, β-nitrostyrene and alcohol/amine using multicomponent reaction
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- 作者：Suchandra Bhattacharjeea ; Abu T. Khana ; b ; atk@iitg.ernet.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Multicomponent reactions (MCRs) ; 4-Hydroxycoumarin ; β-Nitrostyrene ; Alcohol/amine ; N ; N-Dimethyl-4-aminopyridine (DMAP) ; 3-Substituted flavone
- 刊名：Tetrahedron Letters
- 出版年：2016
- 出版时间：27 April 2016
- 年：2016
- 卷：57
- 期：17
- 页码：1831-1834
- 全文大小：746 K
文摘
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A wide range of 3-substituted carboxylate/carboxamide flavone derivatives were synthesized from 4-hydroxycoumarin, β-nitrostyrene and alcohol/amine using multicomponent reaction in presence of N,N-dimethyl-4-aminopyridine (DMAP).
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Good yield, short reaction time, atom economy, cost effective and use of non-toxic organo-catalyst are some of the remarkable advantages of the present protocol.
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The protocol was successful for the synthesis of 3-carboxamide-flavone derivatives, which was not reported earlier.
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All the synthesized compounds were fully characterized by IR, NMR and Mass Spectra.