Long-term deterioration of quality of life in adult patients with celiac disease is associated with treatment noncompliance

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• 作者：Fabio Nachman ; Marcela Planzer del Campo ; Andrea Gonzá ; lez ; Laura Corzo ; Horacio Vá ; zquez ; Cristina Sfoggia ; Edgardo Smecuol ; Marí ; a Iné ; s Pinto Sá ; nchez ; Sonia Niveloni ; Emilia Su
• 关键词：Celiac disease ; Gluten-free diet ; Outcome research ; Quality of life ; Serology
• 刊名：Digestive and Liver Disease
• 出版年：2010
• 出版时间：October 2010
• 年：2010
• 卷：42
• 期：10
• 页码：685-691
• 全文大小：150 K

文摘

Background

Deterioration of quality of life in the long term has been suggested for celiac disease patients on a gluten-free diet.

Aims

To determine long-term quality of life of celiac disease patients and to assess the benefits of gluten-free diet compliance.

Patients

We prospectively evaluated 53 newly diagnosed adult celiac disease patients.

Methods

The Short Form 36 Health Survey, the Gastrointestinal Symptoms Rating Scale and the Beck Depression Inventory were employed at the time of diagnosis, 1 year, and beyond 4 years (median: 53 months) on treatment.

Results

At 1 year, a significant improvement from baseline in quality of life indicators was observed (p < 0.001 to p < 0.0001) with comparable scores to healthy subjects. At 4 years, the Short Form 36 Health Survey scores (p < 0.002 to p < 0.0002) and Beck Depression Inventory score (p < 0.002) show significant deterioration compare with 1 year. Most scores remained significantly better than those at diagnosis (p < 0.03 to p < 0.0005). No changes were detected in the Gastrointestinal Symptoms Rating Scale scores. The long-term impairment of quality of life was attributable to the deterioration of most dimensions in patients who were not strictly compliant with the gluten-free diet (p < 0.05 to p < 0.001).

Conclusions

Long-term deterioration of quality of life outcomes after the first year of gluten-free diet was associated with the lack of strict compliance with the diet.