Discovery of a new selective inhibitor of A Disintegrin And Metalloprotease 10 (ADAM-10) able to reduce the shedding of NKG2D ligands in Hodgkin's lymphoma cell models
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- 作者：Caterina Camodecaa ; Elisa Nutib ; Livia Tepshib ; c ; Silvia Boerod ; Tiziano Tuccinardib ; Enrico A. Sturac ; Alessandro Poggid ; Maria Raffaella Zocchia ; Armando Rossellob ; armando.rossello@farm.unipi.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hodgkin's lymphoma ; NKG2D-L ; ADAM-10 inhibitors ; Sulfonamido-based hydroxamates
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：23 March 2016
- 年：2016
- 卷：111
- 期：Complete
- 页码：193-201
- 全文大小：1107 K
文摘
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Hodgkin's lymphoma is characterized by an overexpression of ADAM-10 with increased release of NKG2D ligands.
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New ADAM-10 selective inhibitors were designed and synthesized.
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Compound 3 showed improved ADAM-10 selectivity over ADAM-17 and MMPs.
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Compound 3 reduced the shedding of NKG2D ligands in three different HL cell lines.