Structural basis for the regulation of nuclear import of Epstein-Barr virus nuclear antigen 1 (EBNA1) by phosphorylation of the nuclear localization signal

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• 作者：Ryohei Nakada^a ; Hidemi Hirano^a ; ^b ; Yoshiyuki Matsuura^a ; ^b ; ^{matsuura.yoshiyuki@d.mbox.nagoya-u.ac.jp}
• 关键词：Nuclear import ; Importin ; NLS ; EBNA1 ; Epstein-Barr virus
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：26 February 2017
• 年：2017
• 卷：484
• 期：1
• 页码：113-117
• 全文大小：1875 K
• 卷排序：484

文摘

Nuclear import of EBNA1 can be regulated by phosphorylation of NLS. Crystal structures of importin-α1 bound to the NLS peptides of EBNA1 are solved. Structures provide insights into how phosphorylation can regulate nuclear import.