Small molecule absorption by PDMS in the context of drug response bioassays

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• 作者：B.J. van Meer^a ; ^{b.j.vanmeer@lumc.nl} ; H. de Vries^b ; ^{vries_h@lacdr.leidenuniv.nl} ; K.S.A. Firth^c ; ^{mzxksf@nottingham.ac.uk} ; J. van Weerd^d ; ^{j.vanweerd@utwente.nl} ; L.G.J. Tertoolen^a ; ^{l.g.j.tertoolen@lumc.nl} ; H.B.J. Karperien^d ; ^e ; ^{h.b.j.karperien@utwente.nl} ; P. Jonkheijm^d ; ^f ; ^{p.jonkheijm@utwente.nl} ; C. Denning^c ; ^{Chris.Denning@nottingham.ac.uk} ; A.P. IJzerman^b ; ^{ijzerman@lacdr.leidenuniv.nl} ; C.L. Mummery^a ; ^g ; ^{c.l.mummery@lumc.nl}
• 关键词：PDMS ; Absorption ; Drug screening ; LipoCoat Cellbinder ; PDMS coating ; Microfluidics
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：8 January 2017
• 年：2017
• 卷：482
• 期：2
• 页码：323-328
• 全文大小：1082 K
• 卷排序：482

文摘

Binding of different compounds to PDMS varies greatly. Previous reported correlations of absorption and LogP values could not be repeated. Topological polar surface area possibly related to compound absorption. A lipid based coating partially obviates compound absorption. Presence of cultured cells affects free drug concentration, but less than substrate.