The Apoptotic Engulfment Machinery Regulates Axonal Degeneration in C. elegans Neurons
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- 作者：Annika L.A. Nichols1 ; 4 ; 5 ; Ellen Meelkop1 ; 4 ; Casey Linton1 ; Rosina Giordano-Santini1 ; Robert K. Sullivan1 ; Alessandra Donato1 ; Cara Nolan1 ; David H. Hall2 ; Ding Xue3 ; Brent Neumann1 ; 6 ; brent.neumann@monash.edu" class="auth_mail" title="E-mail the corresponding author ; Massimo A. Hilliard1 ; m.hilliard@uq.edu.au" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：23 February 2016
- 年：2016
- 卷：14
- 期：7
- 页码：1673-1683
- 全文大小：2676 K
文摘
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WLDS/Nmnat cannot delay axonal degeneration following axotomy in C. elegans
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Axonal degeneration is regulated by the apoptotic engulfment machinery
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The epidermis functions as the axonal engulfing tissue, through CED-1 and CED-6
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Lipid-vesicle-associated molecules CED-7 and NRF-5 regulate axonal degeneration