Axon degeneration: context defines distinct pathways
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- 作者：Matthew J Geden1 ; 2 ; Mohanish Deshmukh1 ; 2 ; mohanish@med.unc.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Current Opinion in Neurobiology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：39
- 期：Complete
- 页码：108-115
- 全文大小：862 K
文摘
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Axotomy, axon apoptosis, and axon pruning engage distinct pathways of degeneration.
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NMNATs and SARM1 are key mediators of axotomy-induced axon degeneration.
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Context of NGF deprivation defines axon degeneration during apoptosis vs pruning.
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Caspases are activated via distinct mechanisms during apoptosis vs pruning.