Axonal transport plays a crucial role in mediating the axon-protective effects of NmNAT
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- 作者：Cheng Fang1 ; Helena Decker2 ; Gary Banker ; bankerg@ohsu.edu" class="auth_mail
- 关键词：WldS ; Wallerian degeneration slowed protein ; cytNmNAT1 ; cytoplasmically targetred NmNAT1 ; mitoNmNAT1 ; mitochondrially targeted NmNAT1 ; OGD ; oxygen-glucose deprivation ; dnMiro ; dominant negative Miro ; GFP ; green fluorescent protein ; RFP ; red fluorescent protein
- 刊名：Neurobiology of Disease
- 出版年：August 2014
- 年：2014
- 卷：68
- 期：Complete
- 页码：78-90
- 全文大小：1746 K
文摘
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NmNAT1 protected hippocampal neurons from axonal degeneration due to oxidative stress or oxygen-glucose deprivation.
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NmNAT1 reduced inhibition of axonal transport following exposure to oxidative stress or oxygen-glucose deprivation.
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Mitochondrial transport was critical for the protective effects of NmNAT1.