Ten years since the discovery of iPS cells: The current state of their clinical application
详细信息 查看全文
- 作者：J. Aznar ; justo.aznar@ucv.es ; J. Tudela
- 关键词：iPS cells ; Embryonic stem cells ; Regenerative medicine ; Cell reprogramming
- 刊名：Revista Clínica Española (English Edition)
- 出版年：2017
- 出版时间：January-February 2017
- 年：2017
- 卷：217
- 期：1
- 页码：30-34
- 全文大小：658 K
- 卷排序：217
文摘
On the 10-year anniversary of the discovery of induced pluripotent stem cells, we review the main results from their various fields of application, the obstacles encountered during experimentation and the potential applications in clinical practice. The efficacy of induced pluripotent cells in clinical experimentation can be equated to that of human embryonic stem cells; however, unlike stem cells, induced pluripotent cells do not involve the severe ethical difficulties entailed by the need to destroy human embryos to obtain them. The finding of these cells, which was in its day a true scientific milestone worthy of a Nobel Prize in Medicine, is currently enveloped by light and shadow: high hopes for regenerative medicine versus the, as of yet, poorly controlled risks of unpredictable reactions, both in the processes of dedifferentiation and subsequent differentiation to the cell strains employed for therapeutic or experimentation goals.