Temporo-parietal theta activity correlates with misery perfusion in arterial occlusive disease

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• 作者：Satoru Ohtomo ; Nobukazu Nakasato ; Hiroaki Shimizu ; Shintarou Seki ; Akitake Kanno ; Toshihiro Kumabe ; Teiji Tominaga
• 关键词：Magnetoencephalography ; Theta activity ; Brain infarction ; Cerebrovascular circulation ; Carotid stenosis
• 刊名：Clinical Neurophysiology
• 出版年：2009
• 出版时间：July 2009
• 年：2009
• 卷：120
• 期：7
• 页码：1227-1234
• 全文大小：646 K

文摘

Objective

Temporo-parietal theta activity (TPTA), often detected in hemispheres with internal carotid (ICA) or middle cerebral artery (MCA) occlusive lesions, is more clearly separated from occipital alpha activity by magnetoencephalography (MEG) than electroencephalography. The present study investigated whether TPTA is correlated with misery perfusion, a surgically correctable type of hemodynamic impairment.

Methods

Awake MEG was measured in 56 patients with ICA or MCA occlusive lesions. Regional cerebral blood flow (rCBF) and regional cerebrovascular reactivity (rCVR) to acetazolamide were measured in the MCA territory by xenon-133 single-photon emission computed tomography. MEG was repeated in 10 patients after vascular reconstruction surgery.

Results

Fourteen patients showed TPTA in the lesion hemisphere (n = 13) or bilaterally (n = 1). The presence of TPTA was significantly correlated with both reduced rCBF and reduced rCVR (P = 0.0009). After surgery, TPTA disappeared in 7 of the 10 studied patients.

Conclusions

The presence of TPTA suggests misery perfusion, which is characterized by reduced rCBF and reduced rCVR.

Significance

MEG can detect the presence of reversible and surgically remediable cerebral ischemia before the development of complete infarction.