Association of serum carotenoids with high molecular weight adiponectin and inflammation markers among Japanese subjects

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• 作者：Koji Suzuki ; Takashi Inoue ; Shuji Hashimoto ; Junichi Ochiai ; Yasuhiro Kusuhara ; Yoshinori Ito ; Nobuyuki Hamajima
• 关键词：Adiponectin ; Carotenoids ; C-reactive protein ; Interleukin-6 ; Cross-sectional study
• 刊名：Clinica Chimica Acta
• 出版年：2010
• 出版时间：6 September 2010
• 年：2010
• 卷：411
• 期：17-18
• 页码：1330-1334
• 全文大小：175 K

文摘

Background

Several studies have reported that serum concentrations of carotenoids and adiponectin are inversely associated with the risk for cardiovascular disease (CVD). However, no studies have investigated the association between serum concentrations of adiponectin and carotenoids in the general population.

Methods

We investigated cross-sectionally whether serum carotenoids are associated with serum high molecular weight (HMW) adiponectin and some inflammatory markers in 437 Japanese subjects (116 men and 321 women) who attended a health examination.

Results

In multiple linear regression analysis adjusted for confounding factors, serum β-carotene concentrations were significantly associated with serum HMW adiponectin concentrations in both sexes (standardized β coefficient = 0.197, p = 0.036 for men; standardized β coefficient = 0.146, p = 0.012 for women). Serum α-carotene and β-carotene concentrations were significantly associated with serum C-reactive protein (CRP) concentrations in men. In women, there were significant negative associations between serum carotenoids concentrations and serum interleukin-6 (IL-6) concentrations. Additional adjustment for serum concentrations of IL-6 or CRP did not significantly affect the association between carotenoids and HMW adiponectin in non-smoking men as well as in women.

Conclusion

Serum β-carotene concentrations were positively associated with serum HMW adiponectin concentrations even after adjustment for possible confounding factors including inflammatory markers.