NOP receptors in the prelimbic cortex have an inhibitory influence on cardiovascular responses induced by restraint stress
详细信息 查看全文
- 作者：Aline Fassini ; Amé ; rica A. Scopinho ; Leonardo B.M. Resstel ; Fernando M.A. Corrê ; a ; fmdacorr@fmrp.usp.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：aCSF ; artificial cerebrospinal fluid ; ANOVA ; analysis of variance ; HR ; heart rate ; IL ; infralimbic cortex ; MAP ; mean arterial pressure ; MPFC ; medial prefrontal cortex ; N/OFQ ; Nociceptin/orphanin FQ ; NOP ; Orphan Opioid Receptor Like-1 (ORL-1) ; PAP ; pulsatile arterial pressure ; PL ; prelimbic cortex ; RS ; restraint stress ; vMPFC ; ventral medial prefrontal cortex
- 刊名：Neuropeptides
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：57
- 期：Complete
- 页码：35-44
- 全文大小：1192 K
文摘
- •
Nociceptin into the PL reduced cardiovascular responses induced by restraint stress.
- •
NOP receptors blockade in PL potentiated pressor and tachycardiac responses induced by acute RS.
- •
UPF-101 blocked the RS-evoked changes following nociceptin administration into the PL.
- •
PL N/OFQ system increase cardiac parasympathetic activity during RS.
- •
Blockade of NOP receptors in the IL did not affect the autonomic responses induced by acute RS.