A potent and selective calcitonin gene-related peptide (CGRP) receptor antagonist, MK-8825, inhibits responses to nociceptive trigeminal activation: Role of CGRP in orofacial pain
详细信息 查看全文
- 作者：Marcela Romero-Reyesa ; mrr7@nyu.edu" class="auth_mail" title="E-mail the corresponding author ; Vanessa Pardia ; 1 ; Simon Akermanb ; 2
- 关键词：CGRP ; calcitonin gene-related peptide ; CFA ; chronic Freund's adjuvant ; TMDs ; temporomandibular disorders ; TNC ; trigeminal nucleus caudalis
- 刊名：Experimental Neurology
- 出版年：2015
- 出版时间：September 2015
- 年：2015
- 卷：271
- 期：Complete
- 页码：95-103
- 全文大小：1052 K
文摘
- •
MK-8825 inhibited nociceptive grooming behaviors in a model of orofacial pain/TMD
- •
MK-8825 attenuated the evoked neuronal activation in the trigeminal nucleus caudalis
- •
MK-8825 had no effect on the release of inflammatory cytokines
- •
Data suggest CGRP is involved in acute orofacial masseteric muscle pain, but not via activating inflammatory mechanisms