Aromatase inhibitors augment nociceptive behaviors in rats and enhance the excitability of sensory neurons
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- 作者：Jason D. Robargea ; b ; jrobarge@iu.edu" class="auth_mail" title="E-mail the corresponding author ; Djane B. Duartea ; c ; djane@unb.br" class="auth_mail" title="E-mail the corresponding author ; Behzad Shariatia ; bshariat@umail.iu.edu" class="auth_mail" title="E-mail the corresponding author ; Ruizhong Wanga ; rewang@iupui.edu" class="auth_mail" title="E-mail the corresponding author ; David A. Flockharta ; b ; 1 ; dflockha@iupui.edu" class="auth_mail" title="E-mail the corresponding author ; Michael R. Vaskoa ; vaskom@iupui.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：AI ; aromatase inhibitors ; PWT ; paw withdrawal threshold ; PWL ; paw withdrawal latency ; DRG ; dorsal root ganglia ; OVX ; ovariectomized ; AP ; action potential ; CGRP ; calcitonin gene-related peptide
- 刊名：Experimental Neurology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：281
- 期：Complete
- 页码：53-65
- 全文大小：1174 K
文摘
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Systemic aromatase inhibitor administration alters nociception in male and OVX rats.
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AI treatment results in mechanical and chemical, but not thermal hypersensitivity.
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Peripheral sensory neurons display enhanced excitability following AI treatment.
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AI treatment does not alter CGRP release from sensory nerve terminals in the spinal cord.