Role of Kv4.3 in Vibration-Induced Muscle Pain in the Rat
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- 作者：Lindsay B. Conner&lowast ; ; Pedro Alvarez&lowast ; ; Oliver Bogen&lowast ; ; Jon D. Levine&lowast ; ; &dagger ; ; Jon.Levine@ucsf.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hand&ndash ; arm vibration syndrome ; neuropathic pain ; voltage-gated potassium channels ; muscle hyperalgesia ; isolectin B4 binding nociceptors
- 刊名：The Journal of Pain
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：17
- 期：4
- 页码：444-450
- 全文大小：482 K
文摘
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Vibration injury produces muscle hyperalgesia.
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Vibration injury depends on isolectin B4 (IB4)-binding nociceptors.
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IB4-binding nociceptors express voltage-gated potassium channel 4.3 (Kv4.3).
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Kv4.3 expression is down-regulated after vibration injury.
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Intrathecal antisense for Kv4.3 messenger RNA produces muscle hyperalgesia.