Computational studies on receptor-ligand interactions between novel buffalo (Bubalus bubalis) nucleotide-binding oligomerization domain-containing protein 2 (NOD2) variants and muramyl dipeptide (MDP)
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- 作者：Biswajit Brahmaa ; 1 ; 2 ; Mahesh Chandra Patraa ; 1 ; Purusottam Mishraa ; Bidhan Chandra Dea ; Sushil Kumara ; Jitendra Maharanab ; Ashutosh Vatsa ; Sonika Ahlawata ; Tirtha Kumar Dattaa ; Sachinandan Dea ; sachinandan@ndri.res.in" class="auth_mail" title="E-mail the corresponding author ; sachinandan@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：NOD2 ; Splicing ; Transcript variants ; Buffalo ; MDP binding
- 刊名：Journal of Molecular Graphics and Modelling
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：65
- 期：Complete
- 页码：15-26
- 全文大小：4091 K
文摘
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Buffalo expresses multiple transcript variants of NOD2 gene.
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Each variant has different number of LRR motifs.
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MD simulation revealed the wild type buNOD2 binds to MDP more strongly.
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Arg850, Glu932, and Arg992 appeared as potential residues for MDP recognition.