The UVB1 Vitamin D analogue inhibits colorectal carcinoma progression
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- 作者：Marí ; a Julia Ferronatoa ; Eliana Noelia Alonsoa ; Norberto Ariel Gandinia ; Marí ; a Eugenia Fermentoa ; Marí ; a Emilia Villegasa ; Mario Alfredo Quevedob ; Juliá ; n Aré ; valoc ; Alejandro Ló ; pez Romerod ; Marcos Lois Rivadullae ; Generosa Gó ; meze ; Yagamare Falle ; Marí ; a Marta Facchinettia ; Alejandro Carlos Curinoa ; acurino@criba.edu.ar" class="auth_mail" title="E-mail the corresponding author
- 关键词：Colorectal cancer ; Analogue ; Calcitriol ; Vitamin D ; Gemini
- 刊名：Journal of Steroid Biochemistry and Molecular Biology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：163
- 期：Complete
- 页码：193-205
- 全文大小：4524 K
文摘
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UVB1 induces apoptotic cell death of HCT116 colorectal carcinoma cells.
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UVB1 inhibits cellular migration and invasion in colorectal carcinoma cell line.
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UVB1 increases E-cadherin and VDR expression in HCT116 cell line.
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UVB1 reduces tumour volume of a xenograft murine model of colorectal cancer.
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UVB1 exhibits greater affinity for the VDR ligand binding domain than calcitriol.