Cyclooxygenase-2 expression in hepatocytes attenuates non-alcoholic steatohepatitis and liver fibrosis in mice
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- 作者：Omar Motiñ ; oa ; 1 ; Noelia Agraa ; 1 ; Rocí ; o Brea Contrerasa ; 1 ; Marina Domí ; nguez-Morenoa ; Carmelo Garcí ; a-Monzó ; nb ; Javier Vargas-Castrilló ; nb ; Cristina E. Carnovalec ; Lisardo Boscá ; a ; f ; Marta Casadod ; f ; Rafael Mayoralf ; g ; M. Pilar Valdecantosa ; Á ; ngela M. Valverdea ; e ; Daniel E. Francé ; sc ; 2 ; frances@ifise-conicet.gov.ar" class="auth_mail" title="E-mail the corresponding author ; Paloma Martí ; n-Sanza ; f ; 2 ; pmartins@iib.uam.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：COX-2 ; cyclooxygenase-2 ; PGE2 ; prostaglandin E2 ; RCD ; regular chow diet ; MCD ; methionine and choline deficient diet ; CCl4 ; carbon tetrachloride ; NAFLD ; non-alcoholic fatty liver disease ; NL ; normal liver ; NAS ; non-alcoholic steatosis ; NASH ; non-alcoholic steatohepatitis ; TG ; triglycerides ; ALT ; alanine transaminase ; IL-6 ; interleukin 6 ; IL-1β ; interleukin 1β ; TNF-α ; tumor necrosis factor α ; TGF-β1 ; transforming growth factor β1 ; MCP-1 ; monocyte chemotactic protein-1 ; CCR2 ; C-C chemokine recepto
- 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：1862
- 期：9
- 页码：1710-1723
- 全文大小：2240 K
文摘
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hCOX-2-Tg mice showed lower NASH hallmarks under MCD diet and
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attenuated liver fibrosis in a CCl4 model by modulating activation of hepatic stellate cells (HSC).
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Continuous hepatic PGE2 production plays a protective role against the development of NASH and hepatic fibrosis.