Antitumor effects of snake venom chemically modified Lys49 phospholipase A₂-like BthTX-I and a synthetic peptide derived from its C-terminal region

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• 作者：Luiz Carlos Gebrim ; Silvana Marcussi ; Danilo L. Menaldo ; Carla S.R. de Menezes ; Auro Nomizo ; Amé ; lia Hamaguchi ; Elisâ ; ngela P. Silveira-Lacerda ; Maria Inê ; s Homsi-Br ; eburgo ; Suely V. Sampa
• 关键词：BthTX-I ; Bothrops jararacussu ; Chemical modification ; BPB ; Synthetic peptide ; Antitumor activity
• 刊名：Biologicals
• 出版年：2009
• 出版时间：August 2009
• 年：2009
• 卷：37
• 期：4
• 页码：222-229
• 全文大小：446 K

文摘

The present work evaluates both in vitro and in vivo antitumor activity of BPB-modified BthTX-I and its cationic synthetic peptide derived from the 115–129 C-terminal region. BPB-BthTX-I presented cytotoxicity of 10–40 % on different tumor cell lines, which were also susceptible to the lytic action of the synthetic peptide. Injection of the modified protein or the peptide in mice, 5 days after transplantation of S180 tumor cells, reduced 30 and 36 % of the tumor size on day 14th and 76 and 79 % on day 60th, respectively, when compared to the untreated control group. Thus, these antitumor properties might be of interest in the development of therapeutic strategies against cancer.