Association between vascular inflammation and non-alcoholic fatty liver disease: Analysis by ¹⁸F-fluorodeoxyglucose positron emission tomography

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• 作者：Hyun Jung Lee^a ; ¹ ; Chang Hee Lee^b ; ¹ ; Sungeun Kim^c ; Soon Young Hwang^d ; Ho Cheol Hong^a ; Hae Yoon Choi^a ; Hye Soo Chung^a ; Hye Jin Yoo^a ; Ji A Seo^a ; Sin Gon Kim^a ; Nan Hee Kim^a ; Sei Hyun Baik^a ; Dong Seop Choi^a ; Kyung Mook Choi^a ; ^{medica7@gmail.com}
• 关键词：Nonalcoholic fatty liver disease ; Inflammation ; Positron emission tomography
• 刊名：Metabolism
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：67
• 期：Complete
• 页码：72-79
• 全文大小：293 K
• 卷排序：67

文摘

Growing evidence suggests that non-alcoholic fatty liver disease (NAFLD) is associated with cardiovascular disease as well as metabolic syndrome. FDG-PET is a novel imaging technique that detects vascular inflammation, which may reflect rupture-prone vulnerable atherosclerotic plaques.MethodsVascular inflammation was measured as the maximum target-to-background ratio (maxTBR), along with various cardiometabolic risk factors in 51 subjects with NAFLD, and compared with 100 age- and gender-matched subjects without NAFLD. The liver attenuation index (LAI), which was measured using computed tomography, was used as a parameter for the diagnosis of NAFLD.ResultsAfter adjusting for age and sex, both maxTBR and LAI values were associated with several cardiometabolic risk parameters. Furthermore, there was a significant inter-relationship between LAI and maxTBR values (r = − 0.227, P = 0.005). Individuals with NAFLD had higher maxTBR values than those without NAFLD (P = 0.026), although their carotid intima–media thickness (CIMT) values did not differ. The proportion of subjects with NAFLD showed a step-wise increment following the tertiles of maxTBR values (P for trend = 0.015). In multiple logistic regression analysis, maxTBR tertiles were independently associated with NAFLD after adjusting for age, gender, systolic blood pressure, triglycerides, HDL-cholesterol, glucose, BUN, creatinine and homeostasis model assessment of insulin resistance (HOMA-IR) (P = 0.030). However, their relationship was attenuated after further adjustment for waist circumference or high sensitive C-reactive protein.ConclusionPatients with NAFLD have an increased risk for vascular inflammation as measured via FDG-PET/CT even without difference in CIMT. (Clinical trials No. NCT01958411, http://www.clinicaltrials.gov/)