Improved Outcome of Refractory/Relapsed Acute Myeloid Leukemia after Post-Transplantation Cyclophosphamide-Based Haploidentical Transplantation with Myeloablative Conditioning and Early Prophylactic Granulocyte Colony-Stimulating Factor-Mobilized Donor Lymphocyte Infusions
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- 作者：Sarita Rani Jaiswal1 ; 2 ; drsaritaranij@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Shamsuz Zaman2 ; Aditi Chakrabarti1 ; 3 ; Subrata Sen4 ; Shashwata Mukherjee4 ; Sneh Bhargava2 ; Kunal Ray5 ; 6 ; Paul V. O'Donnell7 ; Suparno Chakrabarti1 ; 2
- 关键词：Haploidentical ; Post-transplantation cyclophosphamide ; AML ; Refractory ; DLI
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：22
- 期：10
- 页码：1867-1873
- 全文大小：709 K
文摘
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PTCy provides a suitable platform for exploring adoptive immunotherapy after both myeloablative and nonmyeloablative conditioning.
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Early and sequential prophylactic G-CSF–mobilized DLI (G-DLI) after myeloablative conditioning improves progression-free survival with a modest increase in mild to moderate chronic GVHD.
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NK cell alloreactive donor improves outcome after myeloablative conditioning, but prophylactic G-DLI improves the outcome irrespective of NK cell alloreactivity.