Increased levels of CD4+ and CD8+ T cells expressing CCR1 in patients developing allograft dysfunction; a cohort study
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- 作者：Farshad Foroughia ; Aliakbar Amirzargarb ; c ; amirzara@sina.tums.ac.ir" class="auth_mail" title="E-mail the corresponding author ; Pedram Ahmadpoord ; Farshid Noorbakhshb ; Mohsen Nafard ; Mir Saeed Yekaninejade ; Morteza Hosseinzadehb ; Sanaz Keshavarz Shabazb ; Mehri Barabadib ; Mina Ghorbanpoure ; Abdolfattah Sarrafnejada ; saraf@sphtums.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：PBMC ; peripheral blood mononuclear cell ; FACS ; fluorescence-activated cell sorter ; WFG ; well-functioning graft ; GD ; graft dysfunction ; ROC ; receiver operating characteristic ; ESRD ; end-stage renal disease ; IQR ; inter-quartile range ; AUC ; area under the curve ; CI ; confidence interval
- 刊名：Transplant Immunology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：38
- 期：Complete
- 页码：67-74
- 全文大小：1071 K
文摘
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The present study sought to determine whether the expression of sequential chemokine receptors on CD4+, CD8+ T cells in renal allograft can predict clinical episodes.
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Our results demonstrated that, CD4+, CD8+ T cells expressing CCR1 were increased in patients who developed graft dysfunction.
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These findings may prospectively predict allograft dysfunction, and help elucidate the underlying pathogenic mechanisms.